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Nature inspires: preventing inflammations with nanostructures

How the spin-off nanohape was inspired by the properties of a dragonfly's wing to reduce the risk of inflammation in implants.



The Nanoshape team wants to improve the tolerability of implants: With their surface modification technology, they can reduce the risk of inflammation in implants.
The Nanoshape team wants to improve the tolerability of implants: With their surface modification technology, they can reduce the risk of inflammation in implants.

From compliment to complication

In our society, beautiful teeth are increasingly seen as a status symbol, because first impressions are important to many people. A pretty smile and a well-groomed appearance are compliments that go hand in hand with healthy, straight and white teeth. It is therefore not surprising that the number of dental implants placed is constantly increasing. In Germany, around 25 years ago, about 380,000 implants were placed annually, but now the figure is around 1.5 million dental implants per year. Is this the ultimate in flawless appearance and improved quality of life? “Medical implants are here to stay, and they work well. However, from the many conversations we have with those affected, we often hear the sentence, 'I had a problem with my implant.' Although there is an established state of the art, implants always carry a risk of complications. Bacterial inflammation is one of the most common causes,” explains Dr. Patrick Doll, co-founder of nanoshape GmbH. The implants used are usually made of titanium and sandblasted or etched. The resulting structure promotes ingrowth into the bone, but cannot prevent bacteria from settling and forming a so-called biofilm, which in turn can lead to inflammation. Approaches that have already been researched, such as coating the implants with antibiotics or silver, have not yet been successful. Together with his co-founder Litsy Hüschelrath, Doll has developed a new approach that can significantly reduce the risk of inflammation. The founding duo is initially focusing on dental implants, but the technology is applicable to a wide range of implants and other areas of application outside of medical technology.

The metallic surface is modified at nano level using a special high-pressure oxidation process.
The metallic surface is modified at nano level using a special high-pressure oxidation process.

 

The dragonfly as a source of inspiration

“What makes our technology special is the modification of the metallic surface structure of the implants at the nano level using a special high-pressure oxidation process. This gives the surface a bacteria-repellent effect without the need for any additives. We are thus practically creating a passive effect,” explains Doll. The idea arose during his doctoral thesis at the KIT. “I did my doctorate on the micro- and nanostructuring of dental implants at the KIT from 2015 to 2019. Fighting bacteria with nanotechnology was a real hype at the time. In contrast, the approach of bioinspired antibacterial surfaces was relatively new. And as is usual in many projects, you try out a lot of things and at some point you arrive at the desired solution,” recalls the development engineer. ‘I was inspired by nature, by the wing of a dragonfly,’ continues Doll. The insect wing has an antibacterial effect because of the specially shaped nanostructures found there. ”Bacteria are only a few micrometers in size. The surface of the wings is covered with very small structures, which are about ten times smaller than the bacteria themselves. This means that the bacteria have less of a surface to attack and do not adhere as well. Some of them even die on contact with the wing surface,” explains co-founder Hüschelrath. nanoshape makes use of this effect by adapting the structure of the dragonfly wing. The research-based entrepreneurs use a high-pressure oxidation process to create the special nanostructure on the surface. This process involves using high pressure and high temperatures to cause a surface transformation of the metal components. The result is a jagged structure that is smaller than bacteria and thus produces the same antibacterial effect as in dragonflies.

 

The team has had its own laboratory at the Technologiefabrik Karlsruhe since 2024.
The team has had its own laboratory at the Technologiefabrik Karlsruhe since 2024.

From larvae to dragonflies – the current situation

The results of the initial trials were promising. “We tested our technology biologically on a very broad scale with various bacteria and also compared it with the reaction on the dragonfly wings,” says Hüschelrath, describing the approach taken so far. At the end of 2024, the young entrepreneurs began setting up a pilot plant and conducting a clinical study. “We decided to work with a university hospital that specializes in dentistry. We expect the first results of the study in the course of 2025,” Hüschelrath continues. This is an important step towards establishing new processes in medical technology and thus paving the way to market. The founding team is focusing on implant manufacturing companies. These usually have their own production chains for the manufacturing, processing and surface treatment of metal parts on a microstructure scale. “Our technology can be thought of as a downstream step in which the implants are then refined on a nano scale. In the long term, this refinement should take place in the form of the manufacturers' own systems within the production chain,” says Hüschelrath, describing the vision for the future. This vision promises not only hope for those affected, but also relief for the healthcare system. In Germany alone, additional costs in the billions of euros are incurred each year due to inflamed implants of any kind, resulting in sick leave and additional surgeries. “We originally developed our technology for dental implants, but it can easily be adapted to other implants. If we can successfully show that the nanostructure works and reduces the risk of inflammation, we can establish a new state of the art. We want to revolutionize the implant market,” adds Doll.

 

Further links:

 

Images:

  • sarayuth3390 / iStock.com
  • Amadeus Bramsiepe / KIT

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